There are no general "best settings". It depends on your equipment, network and how you want thing to work. That's why we have settings, otherwise we would just set the value to whatever was "best".
Every value has a default, and the default is what is considered to be "best in average". That doesn't mean it's the best for you.
You can find documentation for some settings in the [urlhttps://github.com/UniversalMediaServer/UniversalMediaServer/wiki]wiki[/url] and most are also described in the default configuration files:
https://github.com/UniversalMediaServer ... s/UMS.conf
https://github.com/UniversalMediaServer ... derer.conf
In addition you can find discussions and explanations for many of the settings on this forum.
I don't know the answer to all the things you ask for, but I can try to answer the ones I have an idea about.
If viewing blurays which are remuxes so in MKV format or m2ts is this compressed in anyway when playing through UMS to the TV?
It depends on your renderer and what formats it can play. If your renderer is capable of playing back the format as it is (and the renderer configuration is correct), UMS won't convert the content. If that's not the case, the content will be transcoded into something that the renderer can handle, with compression/quality degradation as a result. You can also configure UMS to transcode anything about a certain bandwidth if your network has limited capacity. That will obviously also lead to quality loss.
Is it possible to play ISOs through UMS and can UMS play all formats and file types?
UMS can play DVD ISOs - I don't think there's any support for Blu-ray ISO's. UMS can handle a lot of formats, but it's impossible to support "all" format and file types. I'd say it can handle all you'd probably need.
If PC is wired and TVs are wireless what is the best setting?
That depends on your wireless network. It doesn't matter for UMS if you use wired or wireless network, but a wireless network usually has much less bandwidth than a wired network. If you have an AC network with a very strong signal, it might perform close to a 1Gbps wired network though. If your wireless network has a bad bandwidth (which is the most common), you might have to reduce the maximum bandwidth that UMS will allow to play high-bitrate content.
For audio settings do I need to tick a ... o the TV?
This depends completely on your equipment and preference.
Do I need to tick "remux videos with tsmuxer" at all?
tsmuxer can remux some content into a MPEG-TS container without reencoding the content. That will lead to less CPU usage for your computer and better video quality, but it only works for some content. tsmuxer has some bugs that means it doesn't work with all devices and/or content, and it's only really relevant if your renderer can't play typical "modern" formats like MKV and MP4, but can play MPEG-TS with x264 inside.
Where files are transcoded from the trasncode folder does this mean its compressed and converted to a format that can be played to the TV?
UMS will automatically transcode content according to the configuration without the use of the transcode folder. The transcode folder is for those instances where the automatic choice isn't what you want. Inside the transcode folder you can select to play any combination of transcoding engine, audio track and subtitles track that you wish.
Any other settings as really not sure which settings are best to view proper blurays without the video and audio quality be touched and compressed?
Again, this really depends on the capabilities of your renderer and your network. If they can both handle blueray content and the configuration is correct, UMS won't transcode content if it doesn't have to.